Vol. 2 No. 1 (2025): SMART-MD Journal of Precision Medicine (Winter 2025)

Winter 2025 Issue Spotlight: Pancreatic Diseases

This edition features a SMART-Approach by Drs Paul and Brand on guidelines on Surveillance for Pancreatic Cancer as a clinical decision support tool (CDS) for physicians.   A more detailed SMART Medical Review on expert management of exocrine pancreatic insufficiency (EPI) with pancreatic enzyme replacement therapy (PERT) is given by expert John Lieb II.   Details on SPINK1 genetic analysis is provided in a SMART-System Review.       

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Let's make precision medicine the forefront of pancreatic cancer detection and treatment from the outset.    

Cover Image:  Three-dimensional structure of a serine protease similar to trypsin (i.e. chymotrypsin) interacting with SPINK1 (from PMID:1870127 visualized with NCBI Structure Summary MMDB: 1CGJ).  The image includes the protease (left) and SPINK1 (right) with structural subchains highlighted in Rainbow color. See Waqar et al for information on the pathophysiology of SPINK1 variants in pancreatitis.